The main active ingredient in Garcinia Cambogia extract for weight loss is HCA (hydroxycitric acid). During the conversion of glucose to fat in the human body, HCA inhibits ATP-citrate lyase, preventing fatty acid synthesis and inhibiting glycolysis.
Common concentrations of HCA in products are 50%, 60%, and 95% (determined by HPLC). In addition, the extract may contain other components such as glucose, inulin, aloe vera powder, and starch.
The HCA in Garcinia Cambogia extract for weight loss is a competitive inhibitor of ECC (extracorporeal membrane oxygenation), reducing ECC activity and decreasing the source of acetyl-CoA, a raw material for the synthesis of fatty acids and cholesterol. This slows down the synthesis of both, reducing fat and cholesterol levels, thereby improving body fat and blood lipid composition and body morphology.
The effect of Garcinia Cambogia extract for weight loss is to limit fat synthesis, rather than promote fat breakdown, which differs from the mechanism of action of previous weight loss supplements. Studies have shown that exercise, Garcinia Cambogia extract, and exercise combined with Garcinia Cambogia extract all have positive effects on lipid metabolism in obese individuals. They can reduce fat synthesis, promote fat consumption, reduce body fat (and blood lipids), and lower BM, BMI, WHR, SST, TST, and AST. The dual intervention effect of exercise combined with Garcinia Cambogia extract is more significant.