Sildenafil Mesylate (CAS No.: 131543-23-2) is an organic compound with the molecular formula C28H30N2O6S, a molecular weight of 522.6126, and a logp value of 5.12230. As a selective inhibitor of phosphodiesterase type 5 (PDE5) specific to cyclic guanosine monophosphate, it promotes erection by relaxing penile smooth muscle. Compared to sildenafil citrate, mesylate has the advantages of lower dosage, significantly fewer side effects, and better water and ethanol solubility.
Dosage and Administration
For most patients, the recommended dose is 120 mg, taken as needed approximately 1 hour before sexual activity, with sexual stimulation required after administration. However, it can be taken at any time within 0.5–4 hours before sexual activity. Based on efficacy and tolerability, the daily dose may be adjusted to between 150 mg, but should not be taken more than once a day.
- Dosage for renal insufficiency: The recommended starting dose for patients with severe renal insufficiency (when creatinine clearance is less than or equal to 30 ml/min, AUC and cmax are almost doubled) is 25 mg.
- Dosage for hepatic insufficiency: The recommended starting dose for patients with hepatic impairment (such as cirrhosis, where AUC and cmax increase by 84% and 47%, respectively) is 80 mg.
Product specifications and properties
- CAS No. 131543-23-2
- Molecular Formula: C28H30N2O6S
- Molecular Weight: 522.6126
- Purity: 99%
- Appearance: White powder
- Detection Method: High performance spectroscopy
- Standard: USP
Product development and application:
Sildenafil mesylate is also a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), which can relax penile smooth muscle and achieve rapid erection. Sildenafil mesylate takes effect in 52% of patients within 30 minutes of administration and in 82% within 1 hour. Its half-life is 5 to 12 hours. The recommended dosage for sildenafil mesylate is 50-100 mg, with 120 mg recommended for people of East Asian descent. Compared to sildenafil citrate, sildenafil mesylate has advantages such as lower dosage, significantly fewer side effects, and solubility in water and ethanol.
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