Smegglutide (CAS No. 910463-68-2) is a next-generation GLP-1 (glucagon-like peptide-1) analog that stimulates insulin secretion in a glucose-dependent manner and can be used to treat type 2 diabetes. Smegglutide's long-acting mechanism is based on structural modification, attaching an 18-carbon fatty acid side chain to the lysine residue at position 26 of the peptide chain. This modification increases the molecular weight of smegglutide and enhances its affinity for albumin by 5-6 times, preventing rapid renal clearance and metabolic degradation, and prolonging its half-life in vivo.
Smegglutide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA). Its structure shares 94% amino acid sequence homology with natural human glucagon-like peptide-1. As the sixth marketed GLP-1RA drug and the third once-weekly long-acting formulation, it is primarily used for glycemic control in adults with type 2 diabetes.
Product Specifications and Properties
- Molecular Formula: C42H69N9O14S;
- Molecular Weight: 956.11;
- CAS Number: 99291-20-0;
- 910463-68-2; Purity: 99%;
- Appearance: White powder;
- Detection Method: High Performance Indication Gauge;
- Standard: USP (United States Patent and Trademark Office).
According to Professor Wei Guohong of the Department of Endocrinology at the First Affiliated Hospital of Sun Yat-sen University, the main mechanism by which semaglutide achieves blood sugar reduction and weight loss is that it can activate GLP-1 (glucagon-like peptide-1) receptors, promoting insulin secretion in a glucose concentration-dependent manner, inhibiting glucagon secretion, delaying gastric emptying to increase satiety, and suppressing appetite by inhibiting the hypothalamic feeding center, thereby achieving the effect of lowering blood sugar and reducing weight.
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